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Genaue Beschreibung der Veranstaltung:
Referent/in:Dr. Alessio Paolo Buccino, Department of Informatics, University of Oslo, Norway
Thema:A computationally-assisted approach to neural electrophysiology
Beschreibung:Bernstein Seminar
Ausführliche Beschreibung:Extracellular electrophysiology is one of the most important and widely-used approach to investigate how the brain functions. Recent advances in both instrumentation, for example Multi-Electrode Arrays with high spatial density and channel count, and computational modeling, give us powerful tools to improve standard techniques involved in the electrophysiological pipeline. The latter consists of several steps, starting with spike sorting, neural cell-type classification and localization, and finally electrical stimulation.
In my talk, I will show how each of the aforementioned steps can benefit from novel methods that combine computer simulations and data-driven approaches. Realistic biophysical simulations can be used, for example, to construct recordings of known-ground-truth for spike sorting evaluation and validation, to employ supervised learning methods, such as deep learning, for cell-type recognition and 3D localization, and to optimize stimulation paradigms that increase cell selectivity and accuracy. Finally, I will discuss some limitations of the conventional biophysical modeling scheme and possible solutions involving more sophisticated techniques.

Literature
Alessio P. Buccino, Michael Kordovan, Torbjørn V. Ness, Benjamin Merkt, Philipp D. Häfliger, Marianne Fyhn, Gert Cauwenberghs, Stefan Rotter, and Gaute T. Einevoll (2018). Combining biophysical modeling and deep learning for multielectrode array neuron localization and classification. Journal of Neurophysiology
Veranstaltende Institution:Bernstein Center Freiburg


Anschrift:
Bernstein Center Freiburg

Hansastr. 9a
79104 Freiburg

Telefon: 0761 203 9556
Fax: 0761 203 9559
Email: contact@bcf.uni-freiburg.de
http://www.bcf.uni-freiburg.de
Weitere Infos:http://www.bcf.uni-freiburg.de/events/bernstein-seminar/20190212_Buccino
Ansprechpartner/in:Prof. Dr. Stefan Rotter
Kontakt:
Email: Stefan.Rotter@biologie.uni-freiburg.de
Zeit:12.02.2019 17:15
Ort:Bernstein Center, 79104 Freiburg, Hansastr. 9a, Lecture Hall
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