Artikelaktionen

Sie sind hier: Startseite Universität im … Veranstaltungskalender Bernstein Seminar | Excitatory-inhibitory …

Bernstein Seminar | Excitatory-inhibitory balance and timing in the hippocampus explored using combinatorial optical stimulation

Many neural circuits are believed to be in close excitatory-inhibitory (E-I) balance. This makes it possible for neurons to receive a broad latent pool of inputs, but 'pay attention' only to a few whose excitation overrides inhibition. Thus E-I balance has important implications for excitability, input gating, and neuronal summation.
Wann 26.11.2019
von 17:00 bis 18:00
Wo Bernstein Center, Lecture Hall (1st floor), Hansastr. 9a
Name
Teilnehmer (Prof. Dr. Upinder S. Bhalla, National Center For Biological Sciences | Bangalore | India)
Termin übernehmen vCal
iCal


Referent/Referentin:
Prof. Dr. Upinder S. Bhalla (National Center For Biological Sciences | Bangalore | India)

Termin:
Dienstag, 26.11.2019, 17:00 Uhr - 18:00 Uhr

Ort:
Bernstein Center, Lecture Hall (1st floor), Hansastr. 9a

Termin übernehmen:
vCal iCal

Ausführliche Beschreibung:

Many neural circuits are believed to be in close excitatory-inhibitory (E-I) balance. This makes it possible for neurons to receive a broad latent pool of inputs, but 'pay attention' only to a few whose excitation overrides inhibition. Thus E-I balance has important implications for excitability, input gating, and neuronal summation. While global balance is well-established, it is unclear how closely E and I balance out at the level of few synapses, and how precisely the timings of the E and I inputs match up. We used optogenetic stimuli in CA3, delivered in a grid pattern, to sample a very wide stimulus space with tight control over timing, subsets, and number of cells. We monitored responses in CA1, with and without inhibitory blockers, to determine the nature and mechanism of balance. We find that E and I are balanced down to a few synapses, and with a timing profile that leads to a distinct form of summation we call subthreshold divisive normalization. This has interesting implications for gating of input subsets and gating in time.



Interne Verantwortlichkeit:
Bernstein Center Freiburg (BCF)

Kontaktperson:
Name: Prof. Dr. em. Ad Aertsen
E-Mail: aertsen@bcf.uni-freiburg.de

Webadresse:
http://www.bcf.uni-freiburg.de/events/bernstein-seminar/announcements/191126_Bhalla.htm

vortrage_uie-veranstaltungsart biologie_uie-themengebiet medizin-und-klinik_uie-themengebiet mikrosystemtechnik_uie-themengebiet neurowissenschaften_uie-themengebiet 2000000000_uie-organisation 2001500001_uie-institut

Weitere Informationen über diesen Termin…

abgelegt unter: