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Bernstein Seminar | Self-organized reactivation maintains and reinforces memories despite synaptic turnover

Long-term memories are believed to be stored in the synapses of cortical neuronal networks. However, recent experiments report continuous creation and removal of cortical synapses, which raises the question how memories can survive on such a variable substrate.
Wann 21.05.2019
von 17:00 bis 18:00
Wo Bernstein Center, Lecture Hall (1st floor), Hansastr. 9a
Name
Teilnehmer (Dr. Michael Fauth, Physikalisches Institut | Universität Göttingen)
Termin übernehmen vCal
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Referent/Referentin:
Dr. Michael Fauth (Physikalisches Institut | Universität Göttingen)

Termin:
Dienstag, 21.05.2019, 17:00 Uhr - 18:00 Uhr

Ort:
Bernstein Center, Lecture Hall (1st floor), Hansastr. 9a

Termin übernehmen:
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Ausführliche Beschreibung:

Long-term memories are believed to be stored in the synapses of cortical neuronal networks. However, recent experiments report continuous creation and removal of cortical synapses, which raises the question how memories can survive on such a variable substrate. Here, we study the formation and retention of associative memory in a computational model based on Hebbian cell assemblies in the presence of both synaptic and structural plasticity. During rest periods, such as may occur during sleep, the assemblies reactivate spontaneously, reinforcing memories against ongoing synapse removal and replacement. Brief daily reactivations during rest-periods suffice to not only maintain the assemblies, but even strengthen them, and improve pattern completion, consistent with offline memory gains observed experimentally. While the connectivity inside memory representations is strengthened during rest phases, connections in the rest of the network decay and vanish thus reconciling apparently conflicting hypotheses of the influence of sleep on cortical connectivity.



Veranstaltende Institution
Bernstein Center Freiburg (BCF)

Kontaktperson:
Name: Prof. Dr. Ulrich Egert
E-Mail: egert@imtek.uni-freiburg.de

Webadresse
http://www.bcf.uni-freiburg.de/events/bernstein-seminar/announcements/190521_Fauth.htm

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